design, synthesis and anti-tubercular activity of novel 1, 4-dihydropyrine-3, 5-dicarboxamide containing 4(5)-chloro-2-ethyl-5(4)-imidazolyl moiety

current researches have showed that n3, n5-diaryl-2, 6-dimethyl -1, 4-dihydropyrine-3, 5- dicarboxamide analogues demonstrate notable anti-tubercular activity. in this study, hantzsch condensation was used to design and synthesize new analogues of dihydropyridine (dhp). different diary carboxamides were inserted at positions 3 and 5 of the dhp ring. 4(5)-chloro-2-ethyl-5(4)-imidazolyl moiety was considered at position 4 of the dhp ring. the structures of prepared ligands were characterized using tlc followed by ft-ir, elemental analysis, mass and proton nmr. results of anti-tubercular activity have indicated all the prepared ligands 3a-f inhibit the mycobacterium tuberculosis growth and the most potent compounds were 3c (3,4-cl) and 3b (4-cl). the in-vitro obtained data are agreement with our computational predictions in terms of partial atomic charge of carbonyl moieties at the positions 3 and 5 of dihydropyridine ring and the logp of the molecules.